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目的探讨咪达唑仑联合地西泮治疗小儿惊厥持续状态的疗效及安全性。方法将西安市儿童医院自2014年1月—2016年12月收治的小儿惊厥持续状态患儿66例作为研究对象,根据入院时间随机分为两组,对照组32例患儿给予地西泮,研究组34例患儿在对照组基础上给予咪达唑仑,观察两组患儿的治疗效果和安全性。结果研究组患者临床有效率为94.12%,对照组为75.00%,组间比较差异有统计学意义(P<0.05)。研究组药物起效时间和惊厥控制时间均少于对照组,差异具有统计学意义(P<0.05)。研究组患儿的呼吸道分泌物增多例数较对照组,但可耐受。结论咪达唑仑联合地西泮治疗小儿惊厥持续状态,起效快,安全有效,可在临床范围内推广使用。
Objective To investigate the efficacy and safety of midazolam combined with diazepam in the treatment of persistent convulsions in children. Methods Sixty-six children with congestive seizures in our hospital from January 2014 to December 2016 in Xi’an Children’s Hospital were enrolled in this study. They were randomly divided into two groups according to the time of admission. Diazepam was given to 32 children in the control group, 34 patients in the study group were given midazolam on the basis of the control group, and the therapeutic effect and safety of the two groups were observed. Results The clinical effective rate was 94.12% in the study group and 75.00% in the control group. The difference between the two groups was statistically significant (P <0.05). The onset time of drug and the time of seizure control in the study group were less than those in the control group, the difference was statistically significant (P <0.05). The study group of children with respiratory secretions increased the number of cases than the control group, but tolerable. Conclusion Midazolam combined with diazepam in children with convulsions continued state, rapid onset, safe and effective, and can be used in clinical practice.