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目的探讨庚型肝炎病毒（ＨＧＶ）感染与机体自身免疫的关系．方法抗ＨＧＶＩｇＧ抗体阳性（ＥＬＩＳＡ法）的各类肝病及其他疾病患者９３例．部分慢性肝炎患者用ＲＴＰＣＲ检测证实为ＨＧＶＲＮＡ阳性．用ＥＬＩＳＡ检测血清中类风湿因子（ＲＦ）、抗双链ＤＮＡ（ｄｓＤＮＡＡｂ）抗体、抗甲状腺球蛋白抗体（ＴＧＡｂ）、抗甲状腺微粒体抗体（ＴＭＡｂ）４种自身抗体．同时用ＥＬＩＳＡ检测乙型肝炎病毒（ＨＢＶ）５项血清标志物（ＨＢｓＡｇ，抗ＨＢｓ，ＨＢｅＡｇ，抗ＨＢｅ，抗ＨＢｃＩｇＧ）和丙型肝炎病毒标志物（抗ＨＣＶＩｇＧ和抗ＨＣＶＩｇＭ）．结果研究对象９３例中有２５例检测出１种以上自身抗体的阳性率为２６９％．其中自身抗体阳性率在单独抗ＨＧＶ阳性者中为１３６％（３／２２）；抗ＨＧＶ阳性合并ＨＢＶ标志物阳性者为１７９％（５／２８）；抗ＨＧＶ阳性合并抗ＨＣＶ阳性者为４００％（１０／２５）；ＨＧＶ，ＨＢＶ，ＨＣＶ标志物全阳性者为３８９％（７／１８）．对照组：自身抗体阳性率为２６１％（３１／１１９）．其中ＨＧＶ，ＨＢＶ，ＨＣＶ标志物全阴性者为１６０％（４／２５）；ＨＢＶ标志物阳性者为２５０％（７／２８）；ＨＣＶ标志物阳性者为２７?
Objective To investigate the relationship between hepatitis G virus (HGV) infection and autoimmunity. Methods Ninety-three patients with various liver diseases and other diseases who were positive for anti-HGVIgG antibody (ELISA method). Some chronic hepatitis patients with RT PCR confirmed HGVRNA positive. Serum levels of autoantibodies such as rheumatoid factor (RF), anti-dsDNA (anti-dsDNAAb) antibody, anti-thyroglobulin antibody (TGAb) and anti-thyroid microsomal antibody (TMAb) were detected by ELISA. Five serum markers of hepatitis B virus (HBsAg, anti-HBs, HBeAg, anti-HBe, anti-HBcIgG) and hepatitis C virus markers (anti-HCVIgG and anti-HCVIgM) were also detected by ELISA. Results The positive rate of more than one autoantibodies detected in 25 of 93 subjects was 26.9%. The positive rate of autoantibodies was 13.6% (3/22) in patients with anti-HGV alone and 17.9% (5/28) in patients with positive anti-HGV and HBV markers. The anti-HGV positive and anti-HCV positive Were 400% (10/25). The positive rate of HGV, HBV and HCV markers was 389% (7/18). In the control group, the autoantibody positive rate was 26.1% (31/119). Among them, 160% (4/25) were HGV, HBV and HCV markers, 250% (7/28) were HBV markers positive, 27 were HCV markers positive.