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磺胺甲噁唑(SMX)作为典型的一类光谱抗生素,经常被用于敏感菌引起的各类感染。由于其晶体内部结构的不同,SMX将以两种不同的多晶型形式存在。不同晶型常常具有不同的物理化学性质,这些差异可能会对药物的流动性、稳定性以及药效等有较大影响。新兴发展起来的太赫兹光谱技术对于分子间弱的相互作用及大分子的骨架振动、偶极子的旋转和振动跃迁以及晶体中晶格的低频振动吸收都非常敏感,在药物以及生物等领域获得了重要的应用。利用太赫兹时域光谱(THz-TDS)技术在室温下对两种不同多晶型SMX类药物在0.2~1.5 THz范围内进行了光谱测量,得到对应的吸收谱,发现其在太赫兹波段都有明显的特征吸收峰,可作为其指纹谱用于该类药物多晶型的识别。不同温度下(95~296 K)获得太赫兹时域波形以及对应的频域吸收谱图,结果发现时域波形以及频域吸收谱均与温度呈现规律变化。该研究结果表明THz-TDS技术药物与生物领域研究、区分药物分子多晶型现象等方面具有重要的应用。
Sulfamethoxazole (SMX) as a typical class of spectrum antibiotics, often used for sensitive infections caused by various types of infections. Due to the different internal structure of the crystal, SMX will exist in two different polymorphic forms. Different crystalline forms often have different physicochemical properties, these differences may have a greater impact on drug flow, stability and efficacy. The newly developed terahertz spectroscopy technique is very sensitive to weak intermolecular interactions and the vibrational vibration of the framework of macromolecules, the dipole rotation and vibration transitions and the low-frequency vibration absorption of crystal lattices in crystals, and is obtained in the fields of medicine and biology The important application. Spectral measurements of two different polymorphic SMXs were carried out using THz-time-domain spectroscopy (THz-TDS) at a range of 0.2-1.5 THz at room temperature. The corresponding absorption spectra were obtained and found to be in the terahertz band There are obvious characteristic absorption peaks, which can be used as the fingerprinting spectrum for the identification of polymorphic forms of these drugs. The terahertz time-domain waveforms and the corresponding frequency-domain absorption spectra were obtained at different temperatures (95 ~ 296 K). The results showed that both the time-domain waveforms and the frequency-domain absorption spectra showed regular changes with temperature. The results show THz-TDS technology in the field of medicine and biology research, to distinguish between drug molecules polymorphism has important applications.