胃肠间质瘤是胃肠道最常见的间叶性肿瘤,因其形态及生物学行为多变,诊断及临床治疗存在较大困难,结合目前国内外对胃肠间质瘤的最新研究进展,介绍胃肠间质瘤临床表现、诊断及治疗。手术治疗仍是胃肠间质瘤的首选方法,主张行局部完整切除,不主张行淋巴结清扫术。对于不能手术及术后复发病例,可选用甲磺酸伊马替尼、苹果酸舒尼替尼进行靶向治疗。 Gastrointestinal stromal tumor is the most common gastrointestinal mesenchymal tumor, because of its morphological and biological behavior change, diagnosis and clinical treatment there is a big difficulty, combined with the current domestic and foreign research and development of gastrointestinal stromal tumors , Introduced gastrointestinal stromal tumors clinical manifestations, diagnosis and treatment. Surgical treatment is still the preferred method of gastrointestinal stromal tumors, advocating a complete line of partial resection, do not advocate line lymph node dissection. For inoperable and postoperative recurrence cases, the choice of imatinib mesylate, sunitinib malate targeted therapy.