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目的分析新疆维吾尔族妇女子宫颈HPV感染类型及其分布的规律。方法采用导流杂交基因分型技术对318名妇科维吾尔族就诊患者进行HPV基因分型检测。结果 HPV-DNA检测阳性者占21.70%(69/318)。低危型感染12例(20.69%),以HPV 6和HPV 1l为主;高危型感染46例(79.31%),以HPV 16、HPV58和HPV68感染为主。多重感染11例,感染率为3.46%。从年龄分布来看,≤25岁的患者占31.48%,HPV感染率最高,其次为50~55岁年龄段的患者占25.71%。结论 HPV分布存在地域和种族差异,加强对新疆各年龄人群,多种型别HPV的筛查,有助于预防宫颈癌的发生及了解HPV感染的转归,并为新疆地区宫颈癌干预提供理论基础。
Objective To analyze the types and distribution of cervical HPV infection in Uighur women in Xinjiang. Methods The genotypes of 318 gynecological Uygur patients were detected by flow cytometry (IHC) genotyping. Results Positive HPV-DNA tests accounted for 21.70% (69/318). 12 cases (20.69%) were infected with low-risk type, mainly HPV 6 and HPV 11; 46 cases (79.31%) were infected with high-risk type, mainly HPV 16, HPV58 and HPV68. Multiple infections in 11 cases, the infection rate was 3.46%. In terms of age distribution, patients ≤25 years of age accounted for 31.48%, HPV infection rate was highest, followed by patients aged 50 to 55 years accounted for 25.71%. Conclusion There are geographical and ethnic differences in the distribution of HPV and the screening of various types and types of HPV in various age groups in Xinjiang is helpful to prevent the occurrence of cervical cancer and understand the prognosis of HPV infection and provide a theoretical basis for cervical cancer intervention in Xinjiang basis.