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目的探讨促肾上腺皮质激素释放激素(CRH)在早产发病中的作用及CRH水平在早产预测诊断中的价值。方法采用放射免疫法测定正常产、早产及抗早产药物治疗前后母体血浆中CRH水平的变化。结果分娩时足月妊娠妇女母体血浆CRH高于早产妊娠妇女,但差异无统计学意义(P>0.05);早产妊娠母体血浆CRH值明显高于先兆早产继续妊娠母体血浆CRH值,两者比较差异有统计学意义(P<0.05);先兆早产孕妇经治疗后继续妊娠者母体血浆CRH水平明显回落,与治疗前相比差异有统计学意义(P<0.05)。结论 CRH可能是人类分娩启动的触发因子,母体血浆CRH水平不仅可能预测早产,也可能成为广大临床医务工作者判断先兆早产治疗效果的有效指标。
Objective To investigate the role of corticotropin-releasing hormone (CRH) in the pathogenesis of prematurity and the value of CRH in the prediction of preterm labor. Methods Radioimmunoassay was used to determine the changes of plasma CRH levels in normal and premature labor and anti-premature drugs before and after treatment. Results The maternal plasma CRH in full-term pregnant women at delivery was higher than that in preterm pregnant women, but the difference was not statistically significant (P> 0.05). The CRH of maternal plasma in preterm labor was significantly higher than that of maternal plasma in threatened premature labor (P <0.05). The level of plasma CRH in maternal plasma of pregnant women with threatened preterm birth after treatment was significantly lower than that before treatment (P <0.05). Conclusions CRH may be the trigger factor for initiation of human delivery. Maternal plasma CRH level may not only predict preterm delivery, but also be an effective indicator for clinical medical workers in judging the therapeutic effect of threatened premature delivery.