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Objective:The aim of this study was to explore the correlation between epithelial to mesenchymal transition (EMT) and chemoresistance of non-smal-celllung cancer (NSCLC). Methods:In vitro, the drug resistance index of cisplatin resistant lung adenocarcinoma cellline (A549/DDP) was detected by CCK-8 assay;the morphological change between A549/DDP cells and lung adenocarcinoma cells (A549) was observed by phase contrast microscope;expression of EMT markers (including E-cadherin and vimentin) and resistance protein, excision repair cross-complementing 1 (ERCC1) was detected by immunocytochemistry. The expression of E-cadherin, vimentin and ERCC1 was investigated by immunohistochemistry in 120 cases of NSCLC, half of that were treated with pre-operative neoadjuvant chemotherapy (neoadjuvant chemotherapy group), and the other underwent surgery alone (simple surgery group). Results:There was a significant dif erence between the IC50 (half maximal inhibitory concentration) of A549/DDP cells (5.20) and A549 cells (1.88) (P