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目的了解支气管异常黏膜组织是否存在肺表面活性物质相关蛋白A(SP-A)的异常表达。方法支气管镜下钳取异常组织黏膜34例,用SP免疫组织化学方法检测SP-A的表达,同时标本行光镜病理学检查。结果(+++)8例(炎症8例);(++)10例(炎症2例,鳞癌8例);(+)6例(均为中分化鳞癌);(-)10例(小细胞癌8例,低分化鳞癌2例)。结论SP-A可能有助支气管黏膜炎症与高恶度肿瘤组织的鉴别。
Objective To investigate the abnormal expression of pulmonary surfactant associated protein A (SP-A) in the abnormal bronchial mucosa. Methods Thirty-four cases of abnormal tissue mucosa were dissected by bronchoscopy. The expression of SP-A was detected by SP immunohistochemistry. The specimens were examined by light microscopy. Results (+++) 8 cases (8 cases of inflammation); (++) 10 cases (2 cases of inflammation and 8 cases of squamous cell carcinoma); (6 cases of moderately differentiated squamous cell carcinoma); (-) 10 cases (8 cases of small cell carcinoma, 2 cases of poorly differentiated squamous cell carcinoma). Conclusion SP-A may help bronchial mucosal inflammation and high-grade tumor tissue identification.