核因子E2相关因子2(Nrf2)调控抗氧化反应元件(ARE)依赖的Ⅱ相解毒酶、抗氧化酶和转运蛋白的表达,调节细胞内氧化还原环境,从而保护机体免受氧化剂和亲电试剂的伤害,达到肿瘤预防的目的;但Nrf2在肿瘤细胞中存在的突变或异常高表达,可能是肿瘤耐药的重要机制之一。为此本文对其相关研究做一综述。 Nuclear factor E2-related factor 2 (Nrf2) regulates the expression of phase II detoxification enzymes, antioxidant enzymes and transporters that are dependent on the antioxidant response element (ARE), regulating the intracellular redox environment and thereby protecting the body from oxidative and electrophilic agents Injury, to achieve the purpose of tumor prevention; but Nrf2 in tumor cells exist in the mutation or abnormally high expression may be one of the important mechanisms of tumor resistance. To this end this article makes a summary of its related research.