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目的观察5-氨基酮戊酸光动力治疗宫颈高危型HPV(HR-HPV)感染的临床疗效和安全性。方法将入组的80例宫颈HR-HPV感染患者随机分为两组,治疗组42例,予20%ALA敷药4h后用635nm红光照射30min,1周1次,共3次,治疗结束后3,6,12个月检测HPV-DNA,对照组38例,不进行任何治疗,直接进行随访。比较两组检测结果及不良反应。结果治疗组在第3个月随访时有28例HRHPV转阴,6个月为31例,12个月时增加1例转阴,但有1例患者再次出现转阳,总转阴率为73.81%。对照组3,6,12个月随访时分别有6例,8例,11例转阴,总转阴率为28.95%。治疗组转阴率明显高于对照组,差异有统计学意义(P<0.01)。治疗组患者出现轻度灼热、疼痛、分泌物增多等,未见严重不良反应。结论 5-氨基酮戊酸光动力治疗宫颈HR-HPV感染安全、有效。
Objective To observe the clinical efficacy and safety of photodynamic therapy of 5-aminolevulinic acid in the treatment of cervical high-risk HPV (HR-HPV) infection. Methods Eighty patients with cervical HR-HPV infection were randomly divided into two groups. The treatment group received 42% of the treatment group. After 4 hours of treatment with 20% ALA, they were irradiated with 635nm red light for 30 minutes and once a week for 3 times. After 3, 6, 12 months, HPV-DNA was detected in 38 cases in the control group, without any treatment and direct follow-up. Compare the two test results and adverse reactions. Results At the third month of follow-up, 28 HRHPV were negative in treatment group, 31 in 6 months and 1 in 12 months. However, 1 patient turned positive again and the total negative conversion rate was 73.81 %. In the control group, there were 6 cases, 8 cases and 11 cases turned negative at 3, 6 and 12 months respectively. The total negative conversion rate was 28.95%. The negative rate of treatment group was significantly higher than that of control group, the difference was statistically significant (P <0.01). The treatment group patients with mild burning, pain, secretions increased, no serious adverse reactions. Conclusion 5-aminolevulinic acid photodynamic therapy of cervical HR-HPV infection is safe and effective.