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本实驗采用2只正常狗,2只腎型和2只神經源型高血压狗研究了利血平、中国蘿芙木总硷和双氫氯噻嗪对血压反应的影响。在給药前、給药第5—10天及停药后血压恢复到正常时,各測去甲腎上腺素升压反应及乙酰甲胆硷降压反应两次,同时观察脉搏变化。結果表明,利血平使去甲腎上腺素升压反应稍加强,蘿芙木总硷降低此升压反应,双氫氯噻嗪无影响。利血平及蘿芙木总硷使乙酰甲胆硷降压反应减少,前者还使乙酰甲胆硷引起的脉搏加速减少,后者无此作用。双氫氯噻嗪的作用不同,它使乙酰甲胆硷的降压反应显著加强,維持时間也延长,这一作用在高血压动物更为明显。神經源型高血压狗在服用双氫氯噻嗪时,注射乙酰甲胆硷引起的脉搏加速反应消失,在腎型高血压狗明显减弱,而在正常狗无改变或稍加强。双氫氯噻嗪对MeCh反应的影响在同时补充氯化鈉或氯化鉀时即不出現,但靜脉注入右旋醣酐以补充血浆容量时不能改变这項影响。本实驗的結果反映了三种降压药的作用机制不同。
In this study, two normal dogs, two kidney and two neurogenic hypertensive dogs to study the effects of reserpine, Chinese Rauwolfin and hydrochlorothiazide on blood pressure response. Before administration, administration of 5-10 days and withdrawal of blood pressure returned to normal, the measured norepinephrine blood pressure response and methacholine antihypertensive response twice, while observing the pulse changes. The results showed that reserpine raised norepinephrine slightly stronger response, total rosuvastatin to reduce this step-up response, hydrochlorothiazide no effect. Reserpine and Rauwolfia total alkaloids decreased methacholine antihypertensive response, the former also slowed down the pulse caused by methacholine, the latter without this effect. Dihydrochlorothiazide different role, which makes the methacholine antihypertensive response was significantly strengthened, the maintenance of time is also extended, this effect is more obvious in hypertensive animals. Neurogenic hypertensive dogs taking hydrochlorothiazide, the injection of methacholine caused by pulse-accelerated response disappeared in the renal hypertensive dogs significantly weakened, while in normal dogs no change or slightly stronger. The effects of dihydrochlorothiazide on the MeCh reaction did not occur when sodium chloride or potassium chloride was added at the same time, but intravenous infusion of dextran to supplement the plasma volume did not alter this effect. The results of this experiment reflect the different mechanism of action of the three antihypertensive drugs.