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目的分析山东省沂源县人粒细胞无形体病发生的危险因素及感染途径。方法对2002-2006年报告的34例可疑人粒细胞无形体病病例进行个案调查,并进行描述性分析,对部分病例进行实验室检测。选择年龄相近、未患过人粒细胞无形体病、同性别、同村居民为对照组,进行1∶2配比的病例对照研究。结果通过单因素分析和非条件logistic回归分析:是否经常从事林间劳动(OR=4.4901,95%CI:1.4348～14.0518,P<0.05)、每日平均劳动时间是否超过1h(OR=4.0408,95%CI:1.3083～12.4806,P<0.05)、居住院内是否有牲畜圈(OR=3.3707,95%CI:1.2883～8.8191,P<0.05)为沂源县感染人粒细胞无形体病的暴露危险因素。结论根据病例临床资料、现场流行病学调查以及病例对照研究,与牲畜(尤其是羊)接触、林间劳动、接触草地等危险因素为该疾病可能的感染途径。对于人粒细胞无形体病有待于进行更加深入的调查和实验室研究。
Objective To analyze the risk factors and infection pathways of human granulocytic anaplasmosis in Yiyuan County of Shandong Province. Methods A total of 34 cases of suspected human granulocytic anaplasmosis reported in 2002-2006 were investigated by case analysis and descriptive analysis was performed. Some cases were tested in laboratory. Select the same age, not suffering from human anaplastic anaplastic disease, same sex, the same village residents for the control group, a 1: 2 ratio of case-control study. The results were analyzed by univariate analysis and non-conditional logistic regression analysis: whether the average daily working time was more than 1h (OR = 4.0908, 95% CI: 1.4348 ~ 14.0518, P <0.05) % CI: 1.3083 ~ 12.4806, P <0.05), and whether there was a livestock ring (OR = 3.3707,95% CI: 1.2883 ~ 8.8191, P <0.05) in the hospital for the risk factors of exposure to human myeloid anaplasmosis in Yiyuan County. Conclusions According to the clinical data, field epidemiological investigation and case-control study, contact with livestock (especially sheep), forest labor, grassland exposure and other risk factors for the possible infection of the disease. For human granulocytoma awaiting further investigation and laboratory studies.