为证实在治疗多发性骨髓瘤(MM)的多药物联合化疗方案中删去皮质类固醇是否能获得同样疗效,作者在1983年1月～1985年7月对138例年龄小于70岁、初始MM患者进行了随机多中心临床试验。在第一疗程的MOCCA方案后分为两组:MOCCA方案组与COLA方案组。MOCCA组包括长春新硷0.03mg/kg iv;环磷酰胺10mg/kg iv;罗氮芥40mg。口服均为第1天;苯丙氨酸氮芥 To confirm whether the removal of corticosteroids could achieve the same effect in multimodal chemotherapy for the treatment of multiple myeloma (MM), 138 patients aged less than 70 years from January 1983 to July 1985 with initial MM A randomized multi-center clinical trial was conducted. After the first course of MOCCA program is divided into two groups: MOCCA program group and COLA program group. The MOCCA group consisted of vincristine 0.03 mg / kg iv; cyclophosphamide 10 mg / kg iv; and carotenoid 40 mg. Oral are the first day; melphalan mustard