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我市第一人民医院自制麩氨酸钠注射液,以配合临床治疗肝性昏迷症。为了确保制剂质量,我們拟定了它的快速定量方法,利用甲醛与氨基的縮合作用,使滴定曲线向酸性方向移动。这个方法比本刊1957年1月号內介紹的兩种定量方法简单易行,适合于药房内快速分析之用。兹介绍如下: 取檢品28.74%麩氨酸鈉注射液2ml,置25ml容量瓶中,加蒸餾水稀釋至刻度。取出稀釋液2ml,加甲醛溶液(36%W/W)2ml,加麝香草酚酞指示剂三滴,以N/10 NaOH溶液滴定至呈淡蓝色。另准确吸取同样的甲醛溶液2ml,加蒸餾水2ml,加麝香草酚酞指示
The first People’s Hospital of our city made glutamic acid sodium injection to meet the clinical treatment of hepatic coma. In order to ensure the quality of the preparation, we developed its rapid quantification method using the condensation of formaldehyde and amino groups to shift the titration curve toward the acidity. This method is simpler than the two quantitative methods described in the January 1957 issue of this publication and is suitable for rapid analysis in pharmacies. It is described as follows: Take 28.74% of sodium glutamate injection 2ml, set 25ml volumetric flask, add distilled water and dilute to the mark. Remove 2 ml of the diluted solution, add 2 ml of formaldehyde solution (36% w/w), add three drops of thymolphthalein indicator and titrate to a light blue color with N/10 NaOH solution. Accurately absorb 2ml of the same formaldehyde solution, add 2ml of distilled water, and add thymolphthalein