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临床工作者迫切需要了解药物的半衰期与最低排泄率,因为这是拟定最佳给药方案的重要依据。可以认为,只有掌握了药物在体内的蓄积和排泄情况,才能达到吸收与消除的平衡、药物血浆浓度的相对稳定和既有疗效而又不致中毒。比如,一次给药后4～5个半衰期血浆浓度下降95%~(+-),那么,连续恒速滴注或重复恒速量给药就要有相应的间隔。在临床上,只有少数药物要在血浆有较高的高峰浓度(如青霉素等),多数药物
Clinicians urgently need to understand the half-life of drugs and the lowest rate of excretion, because this is an important basis for the formulation of the best drug delivery program. It can be considered that only by grasping the accumulation and excretion of drugs in the body can achieve the balance of absorption and elimination, the relative stability of the drug plasma concentration and the curative effect without poisoning. For example, four to five half-life plasma concentrations decrease 95% ~ (+ -) after a single dose, so there should be a corresponding interval between continuous constant drip or repeated constant dose administrations. Clinically, only a small number of drugs in the plasma have a higher peak concentration (such as penicillin, etc.), most drugs