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柱层析常用于甾体药物合成中产物的分离纯化。由于甾体合成产物复杂,分子大,反应物,主、副产物的母核相同,仅在某一部分取代基或构型等上表现出差异,立体结构差别很小,相邻组分的△Rf常小于0.10,所以对柱层析的条件要求高,吸附剂和洗脱剂用量大,分离效果差。为提高分离效率,作者参照胡高云等同志的低压干柱层析改进法(上行展开,下行洗
Column chromatography is often used in the separation and purification of steroidal drug products. Due to the complexity of the synthetic products of the steroid, the mother nuclei of the large molecules, the reactants, the main and the by-products are the same, only show differences in some substituent groups or configurations, and have little difference in the three-dimensional structure. The ΔRf Often less than 0.10, so the column chromatography conditions require high adsorbent and eluent dosage, separation is poor. In order to improve the separation efficiency, the author refers to Hu Gaoyun and other comrades low-pressure dry column chromatography to improve the law (uplink, downlink