Population and housing grid data spatialization based on 340 grid samples( 1 km × 1 km) is used instead of regional statistical data to simulate the population and housing distribution data of Yunnan Province( 1 km × 1 km) for rapid loss assessment for the Jinggu Ms6. 6 earthquake. The results indicate that the method reflects the actual population and housing distribution and that the assessment results are credible. The method can be used to quickly provide spatial orientation disaster information after an earthquake. Population and housing grid data spatialization based on 340 grid samples (1 km × 1 km) is used instead of regional statistical data to simulate the population and housing distribution data in Yunnan Province (1 km × 1 km) for rapid loss assessment for the Jinggu The results indicate that the method reflects the actual population and housing distribution and that the assessment results are credible. The method can be used to quickly provide spatial orientation disaster information after an earthquake.