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目的:探讨脑脊液细胞学检查对诊断脑膜癌病的重要意义。方法:对2005年1月~2007年11月收治的14例经脑脊液细胞学证实为脑膜癌病患者的临床资料进行回顾性分析。结果:14例脑膜癌病患者,男3例,女11例,平均年龄59.75岁±9.65岁,临床病理诊断7例为肺癌,1例为乳腺癌,1例为甲状腺癌,1例为卵巢癌,1例为前列腺癌,原发病灶未查明的3例。首发症状以头痛、呕吐为主,可伴脑神经和脊神经损害及脑膜刺激征,脑脊液检查颅内压均不同程度增高,细胞学检查均发现癌细胞。结论:脑膜癌病为恶性肿瘤颅内转移的特殊形式,脑脊液细胞学检查找到癌细胞是诊断脑膜癌病的重要依据,多次反复检查脑脊液细胞学有助于早期诊断。
Objective: To investigate the significance of cerebrospinal fluid cytology in the diagnosis of meningeal carcinomatosis. Methods: The clinical data of 14 patients with cerebrocellular carcinoma confirmed by cerebrospinal fluid cytology from January 2005 to November 2007 were analyzed retrospectively. Results: Among the 14 cases of meningeal carcinomatosis, there were 3 males and 11 females, with an average age of 59.75 years and 9.65 years. Clinicopathologic diagnosis was 7 cases of lung cancer, 1 case of breast cancer, 1 case of thyroid cancer and 1 case of ovarian cancer , 1 case of prostate cancer, the primary lesion was not identified in 3 cases. The first symptom of headache, vomiting, may be associated with damage to the cranial nerves and spinal nerves and meningeal irritation, cerebrospinal fluid examination were increased intracranial pressure in varying degrees, cytology were found in cancer cells. Conclusion: Meningioma is a special form of intracranial metastasis of malignant tumor. It is an important basis for the diagnosis of meningeal cancer by cytological examination of cerebrospinal fluid. The repeated examination of cerebrospinal fluid cytology can be helpful for early diagnosis.