论文部分内容阅读
上世纪50年代,移植免疫学家Medawar~([1])提出的著名假说阐述了胚胎由于携带一半父系抗原,妊娠对于母体而言属于半同种异体移植物免疫耐受过程。一旦母体免疫功能紊乱,免疫耐受无法维持,将导致不良的妊娠结局的发生。复发性自然流产(recurrent spontaneous abortion,RSA)是指与同一性伴侣连续发生自然流产2次及以上者,近年来随着生存环境的恶化和平均孕龄的提高,约有2%~4%的孕龄夫妇受到此病的影响,严重威胁着
In the 1950s, the well-known hypothesis put forward by the transplant immunologist Medawar ~ ([1]) states that the embryo belongs to the semi-allograft immunotolerance process because it carries half of the paternal antigens. Once the mother immune dysfunction, immune tolerance can not be maintained, will lead to the occurrence of adverse pregnancy outcomes. Recurrent spontaneous abortion (RSA) refers to two or more consecutive spontaneous abortion (ABA) with the same sex partner in recent years, with the deterioration of the living environment and the average gestational age increased, about 2% to 4% Pregnant couple affected by the disease, a serious threat