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过去使用赛庚啶和溴隐亭等药物,对促皮质素的分泌进行神经递质调控,用于治疗柯兴病,其疗效好坏不一。利他赛宁(ritanserin)是一种新型的强力特效药物,尤其对5-羟色胺有长效拮抗作用,这药正受到众多精神病学家重视。也有证明它可降低促皮质素对胰岛素性低血糖的应答反应。本文在三例垂体依赖性柯兴病患者,研究该药的疗效。例1 系57岁老年妇女,做过成功的垂体经蝶手术,7年后皮质醇增多症复发,磁共振影象证实为垂体小腺瘤。经服利他赛宁,每日10mg共1个月。在服药1周后,尿液氢化可的松水平只有轻度暂时性降低达657nmol/d(基
Past use of cyproheptadine and bromocriptine and other drugs, the secretion of corticotropin neurotransmitter regulation, for the treatment of Cushing’s disease, its efficacy varies. Ritanserin is a new potent and potent drug that has long-lasting antagonism of serotonin, and is being taken seriously by many psychiatrists. It has also been shown to reduce the response of corticotropin to insulin-induced hypoglycemia. In this paper, three cases of pituitary-dependent Cochin patients to study the efficacy of the drug. Example 1 Department of 57-year-old woman, had a successful pituitary transversal surgery, 7 years after the recurrence of Cushing’s disease, magnetic resonance imaging confirmed a small pituitary adenoma. The service of altaxan, 10mg daily for a total of 1 month. One week after taking the drug, the level of hydrocortisone in urine was only slightly reduced to 657 nmol / d