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Objective To prepare the PEG-PLGA nanoparticles loaded with vincristine sulfate(VCR-loaded PEG-PLGA-NPs) and evaluate their quality.Methods VCR-loaded PEG-PLGA-NPs were prepared by the double emulsion solvent evaporation method.The main experimental factors,which influenced the physical and chemical properties of the nanoparticles,were investigated and optimized.Results Under optimal conditions,the VCR-loaded PEG-PLGA-NPs had an average diameter of 135.9 nm with narrow size distribution.The encapsulation efficiency was 68.2%,while the drug loading capacity was 8.34%.In vitro,VCR was released from the PEG-PLGA-NPs sustainedly for more than 13 days with the total amount of 81%.Moreover,the VCR-loaded PEG-PLGA-NPs were relatively stable,which was confirmed by the stability testing.Conclusion The VCR-loaded PEG-PLGA-NPs are a promising nano drug with controlled release,which can be applied widely.
Objective To prepare the PEG-PLGA nanoparticles loaded with vincristine sulfate (VCR-loaded PEG-PLGA-NPs) and evaluate their quality. Methods VCR-loaded PEG-PLGA-NPs were prepared by the double emulsion solvent evaporation method. , which influenced the physical and chemical properties of the nanoparticles, were investigated and optimized. Results under optimal conditions, the VCR-loaded PEG-PLGA-NPs had an average diameter of 135.9 nm with narrow size distribution. The encapsulation efficiency was 68.2% While the drug loading capacity was 8.34%. VCR was released from the PEG-PLGA-NPs sustainedly for more than 13 days with the total amount of 81%. Moreover, the VCR-loaded PEG-PLGA-NPs were relatively stable , which was confirmed by the stability testing. Conlusion The VCR-loaded PEG-PLGA-NPs are a promising nano drug with controlled release, which can be applied widely.