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目的比较舍曲林与氯丙咪嗪治疗少年强迫症的临床疗效及不良反应。方法将54例少年强迫症患者随机分为舍曲林组和氯丙咪嗪组,疗程均为8周。分别于入组前、服药2、4、6、8周末应用Yale-Brown强迫量见(Y-BOCS),汉密尔顿抑郁量表(HAMD),汉密尔顿焦虑量表(HAMA)评定疗效,采用副反应量表(TESS)评定不良反应。结果舍曲林组和氯丙咪嗪组治疗后,Y-BOCS、HAMD、HAMA分值均显著下降,差异无显著性。舍曲林不良反应发生率明显少于氯丙咪嗪。结论舍曲林治疗少年强迫症与氯丙咪嗪疗效相当,不良反应较轻。
Objective To compare the clinical efficacy and side effects of sertraline and clomipramine in the treatment of juvenile obsessive-compulsive disorder. Methods 54 cases of juvenile obsessive-compulsive disorder were randomly divided into sertraline group and clomipramine group, the course of treatment was 8 weeks. The Yale-Brown obsessive-compulsive disorder (Y-BOCS), Hamilton Depression Rating Scale (HAMD), and Hamilton Anxiety Scale (HAMA) were used to evaluate the therapeutic effect at 2,4,6,8weeks before enrollment. Table (TESS) to assess adverse reactions. Results After treatment with sertraline and clomipramine, the scores of Y-BOCS, HAMD and HAMA decreased significantly, with no significant difference. The incidence of sertraline adverse reactions was significantly less than clomipramine. Conclusion Sertraline is equivalent to clomipramine in the treatment of juvenile obsessive-compulsive disorder with less adverse reactions.