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小鼠最大耐受量的富硒康６４００ｍｇ·ｋｇ－１（为临床推荐用量的８００倍）口服，观察２周，未见死亡和任何中毒症状。简化机率单位法求出腹腔注射富硒康的ＬＤ５０为１３０．１４ｍｇ·ｋｇ－１（１２２．０６～１３８．７５ｍｇ·ｋｇ－１）。长期毒性实验给大鼠（１００、２００、４００ｍｇ·ｋｇ－１·ｄ－１）和狗（２４、２４０ｍｇ·ｋｇ－１·ｄ－１）连续口服富硒康４５天（相当于临床推荐用量的３～５０倍）。动物在试验期间的食量与体重呈同步增加，行为活动及大小便未见异常改变。试验结束对大鼠和狗的ＥＣＧ，血、尿常规，肝、肾功能等指标检查均无明显异常；对其心、肝、肾、脑等１２个重要脏器与组织的病理组织学检查亦未见明显毒性作用。提示该药长期口服基本安全无毒。
The maximum tolerated dose of selenium-rich Kang 6400mg · kg-1 (800 times the clinical recommended dosage) orally, observed for 2 weeks, no death and any symptoms of poisoning. The simplified probability unit method was used to calculate the LD50 of perfused selenium-rich Kang to 130.14mg · kg-1 (122.06 ~ 138.75mg · kg-1). Long-term toxicity test Continuous oral selenium-enriched constipation was administered to rats (100, 200, 400 mg · kg -1 · d -1) and dogs (24, 240 mg · kg -1 · d -1) for 45 days (corresponding to the clinically recommended dose 3 to 50 times). During the experiment, the appetite and weight of the animals showed a synchronous increase, and no abnormal changes were found in their behavior and urine. The end of the experiment on rats and dogs ECG, blood, urine, liver, kidney function indicators were no significant abnormalities; its heart, liver, kidney, brain and other 12 important organs and tissues of the pathological examination also No obvious toxic effects. Prompt oral long-term basic safe non-toxic.