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目的:研究雌激素受体(ER)、孕激素受体(PR)、人表皮生长因子受体2(C-erb B-2)和细胞增殖核抗原Ki-67(Ki-67)在子宫内膜癌中的临床病理相关性。方法:选取在重庆市渝北区人民医院接受手术治疗且确诊为子宫内膜癌的30例患者,另选取同期经手术切除的30例正常子宫内膜标本,采用免疫组化染色检测子宫内膜癌组织ER、PR、C-erb B-2和Ki-67的表达。结果:ER、PR、C-erb B-2、Ki-67在正常子宫内膜中的表达与子宫内膜癌中的表达,差异具有统计学意义(P<0.05);ER和PR在不同组织分化程度、不同临床分期、不同肌层浸润深度、有无淋巴结转移方面均无明显差异;子宫内膜癌组织分化程度越低、临床分期越晚、肌层浸润深度越深、淋巴结转移,C-erb B-2和Ki-67的表达越高。结论:ER、PR、C-erb B-2和Ki-67的表达与子宫内膜癌的发生发展密切相关,检测其表达可为治疗子宫内膜癌提供重要的参考依据。
Objective: To study the effect of estrogen receptor (ER), progesterone receptor (PR), human epidermal growth factor receptor 2 (C-erb B-2) and cell proliferation nuclear antigen Ki-67 Clinicopathological correlation in membranous cancer. Methods: Thirty patients with endometrial cancer who underwent surgical treatment in Yubei District People’s Hospital of Chongqing were enrolled. Thirty patients with normal endometrium resected during the same period were selected for immunohistochemical detection of endometrium The expression of ER, PR, C-erb B-2 and Ki-67 in cancer tissue were detected. Results: The expressions of ER, PR, C-erb B-2 and Ki-67 in normal endometrium and endometrial carcinoma were significantly different (P <0.05). The expressions of ER and PR in different tissues There was no significant difference in the degree of differentiation, different clinical stages, different myometrial invasion depth and lymph node metastasis. The lower the degree of differentiation of endometrial carcinoma, the later clinical stage, the deeper myometrial invasion, lymph node metastasis, C- The higher expression of erb B-2 and Ki-67. Conclusion: The expressions of ER, PR, C-erb B-2 and Ki-67 are closely related to the occurrence and development of endometrial carcinoma. Detecting the expression of ER, PR, C-erb B-2 and Ki-67 may provide an important reference for the treatment of endometrial carcinoma.