近年来,低剂量CT广泛应用于早期肺癌的筛查,肺内磨玻璃影(ground-glass opacity,GGO)的检出率逐渐升高。多数学者认为它与早期肺腺癌密切相关,其定性诊断和早期治疗对于提高早期肺癌患者的诊断率与生存率具有重要意义。关于GGO的影像学诊断、定位方法及手术方式进展国内外已有许多报道,现重点将近年来与其分子生物学方面相关的研究进展综述如下。 In recent years, low-dose CT is widely used in the screening of early lung cancer. The detection rate of ground-glass opacity (GGO) in the lung is gradually increased. Most scholars think it is closely related to early lung adenocarcinoma, and its qualitative diagnosis and early treatment are of great significance to improve the diagnosis rate and survival rate of patients with early stage lung cancer. There are many reports about the GGO imaging diagnosis, location method and operation method progress at home and abroad. Now we will summarize the research progress of molecular biology related to GGO in recent years.