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目的:探讨小细胞肺癌患者抑郁状态与辅助性T细胞(Th)1/Th2型细胞因子之间的关系。方法:选择小细胞肺癌患者91例,按照汉密尔顿抑郁量表(HAMD)评分标准分为抑郁组41例和无抑郁组50例,并设立健康对照组。用酶联免疫吸附法(ELISA)检测患者外周血中Th1型细胞因子白细胞介素2(IL-2)、干扰素γ(IFN-γ)和Th2型细胞因子白细胞介素4(IL-4)、白细胞介素10(IL-10)的浓度。结果:小细胞肺癌患者外周血中IL-2、IFN-γ水平较健康组明显下降,IL-4I、L-10水平较健康组显著升高。而与无抑郁组比较,抑郁组外周血中IL-2、IFN-γ水平下降更为明显,IL-4I、L-10水平升高更为显著。结论:小细胞肺癌患者外周血中的Th1/Th2型细胞因子明显失衡,细胞免疫功能低下,尤其是伴有抑郁障碍者细胞免疫功能低下更为显著。因此,尽早识别和治疗小细胞肺癌伴抑郁障碍者具有重要意义。
Objective: To investigate the relationship between depression status and helper T cell (Th)1/Th2 cytokines in patients with small cell lung cancer. Methods: A total of 91 patients with small cell lung cancer were selected. According to the Hamilton Depression Rating Scale (HAMD) score, 41 patients were divided into depression group and 50 patients without depression group. A healthy control group was established. Detection of Th1 cytokines interleukin-2 (IL-2), interferon gamma (IFN-γ) and Th2 cytokine interleukin-4 (IL-4) in peripheral blood by enzyme-linked immunosorbent assay (ELISA) Interleukin 10 (IL-10) concentration. Results: The levels of IL-2 and IFN-γ in peripheral blood of patients with small cell lung cancer were significantly lower than those in the healthy group. The levels of IL-4I and L-10 were significantly higher than those in the healthy group. Compared with the non-depression group, the levels of IL-2 and IFN-γ in the peripheral blood of the depression group decreased more significantly, and the levels of IL-4I and L-10 increased more significantly. CONCLUSIONS: Th1/Th2 cytokines in peripheral blood of patients with small cell lung cancer are significantly out of balance and cellular immune function is low, especially in those with depressive disorder. Therefore, it is important to identify and treat small cell lung cancer with depressive disorder as soon as possible.