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Objective: The aim of this study was to explore expression and correlation of Ezrin and survivin in non-small cell lung cancer (NSCLC). Methods: Expression of Ezrin and survivin were detected and analyzed by Envision method of immunohistochemical staining in 86 NSCLC. Results: The strong expression rate of Ezrin in NSCLC was 60.5% and significantly correlated with lymph node metastasis (P ＜ 0.05), but no associated with gender, histologic subtype, TNM stages, differentiation and smoking. Meanwhile, the positive expression rate of survivin in NSCLC was 65.1% and significantly correlated with TNM stages and lymph node metastasis (P ＜ 0.05), but no associated with gender, histologic subtype, differentiation and smoking. And expression of Ezrin and survivin were positively correlated in NSCLC (r = 0.384). Conclusion: Ezrin and survivin may play synergetic roles in the process of carcinogenesis of NSCLC, and their expression may be significantly associated with NSCLC metastasis. Detection of Ezrin and survivin may be valuable for diagnosing lung cancer metastasis andproviding evidence for clinical treatment.