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目的分析单核细胞趋化蛋白-1基因多态性与Ⅱ型糖尿病患者并发肾功能衰竭之间的相关性。方法随机选取我院50例单纯Ⅱ型糖尿病患者,称为DM组;选取50例Ⅱ型糖尿病合并肾功能衰竭患者,称为DM+组;另外选取50例健康人员进行对照分析,称为NC组。所有患者均采用聚合酶链反应限制性片段长度多态性技术进行分析。结果 NC组和DM组患者的等位基因分布无统计学差异(P>0.05);DM组和DM+组患者的等位基因分布无统计学差异(P>0.05);DM+组患者的A等位基因出现的频率明显高于DM组,差异有统计学意义(P<0.05)。结论单核细胞趋化蛋白-1基因的A等位基因出现频率,和Ⅱ型糖尿病患者并发肾功能衰竭具有一定的相关性。
Objective To analyze the association between monocyte chemotactic protein-1 gene polymorphism and type 2 diabetic patients with renal failure. Methods Fifty patients with simple type II diabetes mellitus in our hospital were randomly selected and named DM group. Fifty patients with type II diabetes mellitus and renal failure were selected as DM + group. Another 50 healthy individuals were selected as control group and named as NC group. All patients were analyzed by polymerase chain reaction restriction fragment length polymorphism. Results There was no significant difference in allele distribution between NC group and DM group (P> 0.05). There was no significant difference in allele distribution between DM group and DM group (P> 0.05) Gene frequency was significantly higher than the DM group, the difference was statistically significant (P <0.05). Conclusion The frequency of the A allele of monocyte chemotactic protein-1 gene is associated with renal failure in patients with type II diabetes mellitus.