论文部分内容阅读
目的 :监测军队人群流感病毒抗体水平 ,获知易感人群的比例 ,了解流感毒株的变异幅度及流行趋势。方法 :1997年秋和 1998年春 2次共采集 954例军人血清 ,应用近 4年 8种国内及国际流感病毒代表株 ,以微量半加敏血凝抑制方法进行了抗体检测。结果 :军队人群中甲3亚型流感病毒抗体水平较高 ,A/山东 / 9/ 93(H3N2 )、A/汉防 / 359/ 95(H3N2 )抗体阳性率为 89%～77% ,抗体平均滴度 (GMT)最高达 58。该人群对近年来 4种不同甲1亚型毒株的抗体水平存在很大差异。A/桂防 / 10 / 94 (H1N1)抗体阳性率为 84 % (97秋 )和 89% (98春 ) ,GMT分别为 90和 134;最新国内代表株A/京防 / 53/ 97(H1N1)抗体阳性率明显偏低 ,为 18% (97秋 )和 30 % (98春 ) ,GMT分别为 2 5和 33。军队人群对乙型流感的抵抗力始终偏低 ,其B/京防 / 184 / 93、B/深防 / 12 / 97抗体阳性率为 4 1%～ 55% ,GMT为 2 7～ 35。结论 :该部队人群甲3亚型株抗体已达饱和水平 ,提示抗原可能会发生变异 ,在一些地区引起流感中度流行甚或出现新亚型而引起大规模流行。H1N1毒株可能在军营中引起局部流行 ,对此应加强预测预报工作。
OBJECTIVE: To monitor the level of influenza virus antibodies in the military population, obtain the proportion of susceptible populations and understand the variation range and epidemic trend of influenza strains. METHODS: A total of 954 military sera were collected twice in the autumn of 1997 and the spring of 1998. Eight domestic and international influenza virus strains were used in the past four years. The detection of antibodies was performed by the method of micro-hemostatic hemagglutination inhibition. Results: The antibody level of Influenza A (subscript 3) subtype influenza among the army population was high. The positive rates of A / Shandong / 9/93 (H3N2) and A / HB / 359/95 (H3N2) were 89% -77% Titer (GMT) up to 58. The population of 4 different strains of subtype A 1 in recent years there is a big difference in antibody levels. The positive rates of A / Gui’ai / 10/94 (H1N1) antibody were 84% (97 autumn) and 89% (98 spring) respectively, with GMTs of 90 and 134 respectively. The latest domestic representative strain A / Jing Fang / 53/97 ) Antibody positive rate was significantly lower, 18% (97 autumn) and 30% (98 spring), GMT were 25 and 33 respectively. The resistance of the army population to influenza B was always low. The positive rate of B / Jing Fang / 184/93 and B / Shen Fang / 12/97 was 41% -55% and GMT was 27-35. CONCLUSIONS: The antibody level of subtype A 3 subunit of this unit has reached the saturation level, suggesting that the antigens may be mutated. In some areas, moderate or even severe subtypes of influenza are caused and caused by pandemic. H1N1 strains may cause local epidemics in the barracks, which should strengthen the forecasting work.