近年来,人乳头瘤病毒(human papillomavirus,HPV)感染作为恶性肿瘤的病因被广泛研究。据估计,80%的侵袭性宫颈癌是由HPV1 6/1 8的感染引起[1]。在头颈癌中,尤其是扁桃体癌,HPV也被公认具有致癌作用[2]。随着研究的深入,HPV作为喉癌的高危因素越来越引起人们的关注。国内最近的一个关于HPV与喉癌的Meta分析[3]表明喉癌中存在HPV的阳性表达,高危型明显多于低危型,而 In recent years, human papillomavirus (HPV) infection has been extensively studied as a cause of malignant tumors. It is estimated that 80% of invasive cervical cancers are caused by HPV1 6/1 8 infection [1]. In head and neck cancer, especially tonsil cancer, HPV is also known to have carcinogenic effects [2]. With the deepening of research, HPV has drawn more and more attention as a risk factor for laryngeal cancer. A recent domestic meta-analysis of HPV and laryngeal cancer [3] showed that HPV-positive expression in laryngeal cancer, high-risk type was significantly more than low-risk type, and