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一氧化氮是一种有害气体.低浓度吸入后可经肺泡弥散于肺血管平滑肌内,从而舒张肺循环血管.弥散于血流的一氧化氮,直接与血红蛋白结合,转化成高铁血红蛋白,使之失活.研究表明,吸入低浓度一氧化氮,可不同程度地降低肺动脉高压.在吸入一氧化氮浓度低于100ppm下,未发现有明显的毒副作用.本文就其研究历史,吸入一氧化氮对肺动脉高压的作用,其选择性作用于肺循环的机理、毒副作用、吸入方法等进行了回顾,并简要地提出尚需解决的问题.一氧化氮可能会成为真正特异性肺血管舒张剂.
Nitric oxide is a noxious gas, which can be diffused in the pulmonary vascular smooth muscle by pulmonary alveolus after inhaling at a low concentration, thus relaxing the vascular circulation of the pulmonary circulation, and the nitric oxide diffused in the bloodstream directly binds to hemoglobin and is transformed into methemoglobin, The study showed that inhaled low concentrations of nitric oxide can reduce pulmonary hypertension to varying degrees in the inhalation of nitric oxide concentrations below 100ppm, no significant side effects found.In this paper, the history of its study, inhalation of nitric oxide The role of pulmonary hypertension, its mechanism of selective action on the pulmonary circulation, toxic and side effects, inhalation and so on are reviewed, and the problems to be solved are briefly proposed.Nitric oxide may become a truly specific pulmonary vasodilator.