口腔黏膜组织工程主要应用于修复因肿瘤切除、牙周病、外伤等导致的软组织缺损。以前的组织工程研究主要围绕上皮细胞培养方法的发展以及结缔组织支架材料的研发开展,本文将对口腔黏膜组织工程替代物的培养模式、支架结构、基质功能及临床应用进行综述,展示组织工程的新视角及口腔黏膜组织工程的新应用。 Oral mucosal tissue engineering is mainly used to repair soft tissue defects caused by tumor resection, periodontal disease and trauma. Previous tissue engineering research focused on the development of epithelial cell culture and the development of connective tissue scaffolds. In this paper, we reviewed the culture patterns, scaffolds, matrix functions and clinical applications of surrogate oral mucosal tissue engineering to demonstrate the advantages of tissue engineering New Perspectives and New Applications of Oral Mucosal Tissue Engineering.