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目的:分析我院醒脑静注射液的使用情况,为临床合理用药提供参考。方法:以药品说明书和循证医学证据为依据,对我院2009年使用醒脑静的全部出院病例,从西医适应证、中医适应证、用法用量、疗程及配伍等方面进行分析评价。结果:274例调查病例中,4.4%使用醒脑静的患者西医适应证与药品说明书不符,4.4%缺乏临床研究证据支持;175例中医病例中,9.1%与药品说明书不符,32.0%缺乏临床研究证据支持;中风证型的选择总体上实证多于虚证,基本与药品说明书和临床研究证据一致;4.7%高于说明书推荐的常用量和临床研究常用量;3.3%不符合说明书推荐的溶媒量;平均疗程7.5d,7.6%超过15d;24.1%与胰岛素混合静脉给药,25.9%与10%氯化钾混合静脉给药。结论:我院醒脑静注射液的使用基本合理,但尚需更多临床研究证据的支持。
Objective: To analyze the use of Xingnaojing injection in our hospital and provide reference for clinical rational drug use. Methods: Based on the drug instructions and evidence based on evidence-based medicine, we analyzed and evaluated all hospital discharge cases in 2009 using western medicine indications, indications for traditional Chinese medicine, dosage, course of treatment, and compatibility. Results: Of the 274 investigations, 4.4% of patients using Xingnaojing had inconsistent Western medicine indications with the drug instructions, and 4.4% lacked clinical research evidence. Among the 175 cases of traditional Chinese medicine, 9.1% were inconsistent with the drug label, and 32.0% lacked clinical research. Evidence support; The selection of stroke syndromes is generally more evidence-based than the deficiency syndrome, which is basically consistent with the drug description and clinical research evidence; 4.7% is higher than the manual’s recommended amount used and the clinical study’s commonly used amount; 3.3% does not meet the specification’s recommended amount of solvent The average course of treatment was 7.5d, 7.6% was more than 15d; 24.1% was mixed intravenously with insulin, and 25.9% was mixed with 10% potassium chloride intravenously. Conclusion: The use of Xingnaojing Injection in our hospital is basically reasonable, but more clinical research evidence is needed to support it.