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目的:研究秋水仙碱对日本血吸虫感染的小鼠肝葡糖胺基聚糖(GAG)代谢的影响.方法:被日本血吸虫感染6—16 wk的小鼠用秋水仙 碱治疗,测量小鼠肝GAG的含量.显微镜观察感染后第6,10,13 wk小鼠肝脏组织切片.结果:感染6 wk以后,小鼠肝GAG含量显著高于未感染的对照组.GAG含量在第10 wk达到最高峰,约为正常水平的6倍:感染组为56±9 μg/g,无感染组为10+1 μg/g,10 wk后,无感染组GAG水平开始下降.秋水仙碱治疗使感染10 wk小鼠的GAG含量比感染对照组降低了约50％,即22±3 μg/g,说明在第10 wk秋水仙碱不能使GAG含量下降到正常水平以下.结论:秋水仙碱可能通过抑制肉芽组织的形成从而降低被日本血吸虫感染的小鼠肝GAG的含量.
Aims: To study the effect of colchicine on hepatic glycosaminoglycan (GAG) metabolism in mice infected with Schistosoma japonicum.Methods: Mice infected with Schistosoma japonicum for 6-16 weeks were treated with colchicine, GAG content.Groups of liver tissues were observed under the microscope at the 6th, 10th and 13th week after infection.Results: After 6 weeks of infection, the hepatic GAG content of mice was significantly higher than that of the untreated control group Peak, about 6 times of the normal level: 56 ± 9 μg / g in the infected group and 10 + 1 μg / g in the non-infected group. After 10 wk, the GAG level in the non-infected group began to decline. The GAG content of wk mice was reduced by about 50%, ie 22 ± 3 μg / g, from the infected control group, indicating that GAG levels could not be reduced below the normal level by colchicine at the tenth week.Conclusion: The formation of granulation tissue thus reduces the hepatic GAG content in mice infected with Schistosoma japonicum.