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目的:通过检测P16和CK17在宫颈不成熟鳞化(AIM)和高级别鳞状上皮内瘤变(CINⅢ级)中的表达,探讨其临床病理意义。方法:采用免疫组化法检测P16和CK17在宫颈成熟鳞化(12例)、AIM(18例)和CINⅢ级(20例)表达情况。结果:12例宫颈成熟鳞化的病例均P16(-)/CK17(-),20例CINⅢ级均P16(+)/CK17(-),18例诊断为AIM的病例,3例P16(+)/CK17(+),5例P16(+)/CK17(-),均重新归入CINⅢ;10例P16(-)/C K17(+),归为鳞化。结论:AIM作为一个诊断性描述的名称,部分包含了CINⅢ级病变;免疫组化检测P16和CK17的表达在一定程度上有助于区分这两种病变。
Objective: To investigate the clinicopathological significance of P16 and CK17 in immature cervical squamous cell carcinoma (AIM) and high grade squamous intraepithelial neoplasia (CIN Ⅲ). Methods: Immunohistochemistry was used to detect the expression of P16 and CK17 in squamous cell carcinoma of the cervix (12 cases), AIM (18 cases) and CIN Ⅲ grade (20 cases). Results: In all 12 cases of squamous cervical squamous cell carcinoma, P16 (-) / CK17 (-), 20 cases of CIN Ⅲ grade were P16 (+) / CK17 (-), 18 cases were diagnosed as AIM, / C17 (+) and 5 cases of P16 (+) / CK17 (-) were re-classified into CIN III; 10 cases of P16 (-) / C K17 (+) were classified as squamous. Conclusion: AIM as a diagnostic description of the name, part of the CIN Ⅲ-level lesions; immunohistochemical detection of P16 and CK17 expression to a certain extent, help to distinguish between the two lesions.