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[背景]长期航空噪声暴露可能增加心血管疾病的风险,但尚无对代谢系统慢性作用的研究。[目的]本文探讨长期航空噪声暴露对体质指数(BMI)、腰围和2型糖尿病的影响。此外,我们还探讨了睡眠障碍对此的修正作用。[方法]这项在瑞典斯德哥尔摩居民中进行的前瞻性队列研究对5 156名参加者进行了长达10年的随访。这些参加者的基线口服葡萄糖耐量试验(OGTT)正常。根据居住史估计航空噪声暴露。从基线和随访调查及检测中获得有关结果和混杂因素的信息;由参加者自我报告医师的诊断、或进行OGTT来确定糖尿病前期或2型糖尿病。采用线性、logistic和随机效应模型对调整后的关联进行评估。[结果]在随访期间,BMI和腰围的均数(±SD)分别增加(1.09±1.97)kg/m2和(4.39±6.39)cm。糖尿病前期和2型糖尿病的累积患病率分别为8%和3%。基于有序噪声变量,经充分调整后,航空噪声每增加5 d B(A)与腰围增加1.51 cm(95%CI:1.13~1.89)相关。这种相关性在那些研究期间未曾改变他们家庭住址的参加者中表现得尤为强烈,这一结果可能是因为本研究的暴露分类错误较少。但是,并未发现航空噪声与BMI或2型糖尿病之间存在明确的相关性。此外,睡眠障碍对上述关联无影响。[结论]长期航空噪声暴露可能与代谢结局,特别是是腰围增加相关。
[Background] Long-term aviation noise exposure may increase the risk of cardiovascular disease, but there are no studies on the chronic effects of the metabolic system. [Objective] This article discusses the effects of long-term aviation noise exposure on body mass index (BMI), waist circumference and type 2 diabetes mellitus. In addition, we also examined the effects of sleep disorders on this correction. [Methodology] This prospective cohort study of residents in Stockholm, Sweden, conducted a total of 5,156 participants over 10 years of follow-up. Baseline Oral Glucose Tolerance Test (OGTT) was normal for these participants. Estimation of aviation noise exposure based on occupancy history. Information about outcome and confounding factors is obtained from baseline and follow-up surveys and tests; participants are self-reported by their physician’s diagnosis or OGTT to determine pre-diabetes or type 2 diabetes. The adjusted associations were assessed using linear, logistic and random effects models. [Results] During follow-up, mean (SD) BMI and waist circumference increased (1.09 ± 1.97) kg / m2 and (4.39 ± 6.39) cm, respectively. The cumulative prevalence of pre-diabetes and type 2 diabetes was 8% and 3%, respectively. Based on the orderly noise variables, B (A) increased by 1.51 cm (95% CI: 1.13 to 1.89) for each 5-day increase in aviation noise after adequate adjustments. This correlation was particularly strong among participants who did not change their home address during the study period, a likely result of the less misdirected exposure in this study. However, no clear correlation was found between aviation noise and BMI or type 2 diabetes. In addition, sleep disturbances have no effect on these associations. [Conclusion] Long-term aviation noise exposure may be related to metabolic outcome, especially increased waist circumference.