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目的研究肝细胞性肝癌患者早期复发转移与感染乙型肝炎核心抗体(HBc)相关性。方法选择2011年4月-2013年11月收治的73例干细胞性肝癌患者,根据术后复发转移的时间分为早期复发组38例和非早期复发组35例,对两组患者的肝炎状态、术中肿瘤进行记录,采取ELISA法检测两组患者的血清抗-HBc水平,分析两组患者的临床因素和肿瘤因素,观察两组患者血清抗-HBc的阴阳性情况。结果早期复发组与非早期复发组患者的肝硬化以及ALT因素差异有统计学意义(P<0.05),其中早期肝硬化程度为阳性的患者占81.58%,明显多于非早期复发组肝硬化程度为阳性患者的54.29%,ALT≥80U/L的早期复发组患者占47.37%,显著多于非早期复发组患者的17.14%;早期复发组与非早期复发组患者的微血管侵犯以及肿瘤直径差异有统计学意义(P<0.05),其中肿瘤直径≥5cm的早期复发组占81.58%,明显高于非早期复发组的34.29%,有微血管侵犯的患者早期复发组占34.21%,显著高于非早期复发组的5.71%。结论肝细胞性肝癌早期复发转移危险因素有多种不同样,尤其是HBc作为患者术后复发转移的重要指标,为此需要在术后对患者保持密切的随访,提高术后复发转移的早期诊断率。
Objective To investigate the correlation between early recurrence and metastasis of hepatocellular carcinoma (HCC) and hepatitis B core antibody (HBc) infection. Methods Seventy-three patients with S-cell carcinoma from April 2011 to November 2013 were divided into 38 cases of early recurrence and 35 cases of non-early recurrence according to the time of recurrence and metastasis. The hepatitis status, Intraoperative tumor records were performed. Serum levels of anti-HBc in both groups were measured by ELISA. Clinical and tumor factors were analyzed in both groups. The anti-HBc sero-positive and negative in both groups were observed. Results There were significant differences in the cirrhosis and ALT between the early recurrence group and the non-early recurrence group (P <0.05), of which 81.58% were positive in the early stage of liver cirrhosis, significantly higher than those in the non-early recurrence group Positive patients, 54.29% of patients with positive ALT≥80U / L, 47.37% of patients with early recurrence, and 17.14% of patients with non-early recurrence; microvascular invasion and tumor diameter in early recurrence group and non-early recurrence group were (P <0.05). The early recurrence group with tumor diameter≥5cm accounted for 81.58%, which was significantly higher than that of non-early recurrence group (34.29%). The early recurrence group with microvascular invasion accounted for 34.21%, which was significantly higher than that of non-early stage 5.71% of the recurrence group. Conclusion There are many different risk factors for early recurrence and metastasis of hepatocellular carcinoma, especially HBc as an important indicator of postoperative recurrence and metastasis of patients with hepatocellular carcinoma. Therefore, it is necessary to maintain close follow-up after operation and improve the early diagnosis of recurrence and metastasis rate.