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目的探讨树突细胞刺激的细胞因子诱导的杀伤细胞(DC-CIK)免疫治疗改善结直肠癌术后患者化疗后的生存质量的效果。方法结直肠癌患者52例随机均分为两组:B组采取单纯化疗方案;A组加用DC-CIK细胞免疫治疗。比较两组患者化疗后的生活质量(QOL)评分及不良反应发生情况。结果A组治疗后QOL总分高于B组[(84.3±9.8)分vs.(71.9±9.2)分](P<0.05)。A组骨髓抑制、消化道反应和腹泻发生率均低于B组(P<0.05)。结论联合应用DC-CIK细胞免疫治疗能提高结直肠癌化疗患者生活质量,降低化疗不良反应。
Objective To investigate the effect of dendritic cell-stimulated cytokine-induced killer (DC-CIK) immunotherapy on postoperative chemotherapy in patients with colorectal cancer. Methods Fifty-two patients with colorectal cancer were randomly divided into two groups: Group B received chemotherapy alone; Group A plus DC-CIK cell immunotherapy. Quality of life (QOL) scores and adverse reactions after chemotherapy were compared between the two groups. Results The total QOL score of group A after treatment was significantly higher than that of group B (84.3 ± 9.8 vs 71.9 ± 9.2) (P <0.05). The bone marrow suppression, digestive tract reaction and diarrhea incidence in group A were lower than those in group B (P <0.05). Conclusions The combination of DC-CIK cell immunotherapy can improve the quality of life of patients with chemotherapy of colorectal cancer and reduce the adverse reaction of chemotherapy.