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我们按Ｗｉｇｇｅｒ法建立失血性休克晚期家兔模型。结果发现失血性休克晚期家兔红细胞超氧化物歧化酶（ＳＯＤ）活性明显下降，血浆丙二醛（ＭＤＡ）、血液乳酸盐（ＢＬ）及血浆镁离子（Ｍｇ２＋）浓度显著上升，提示失血性休克晚期存在由氧自由基所致的细胞膜脂质过氧化损伤。我们将丹参＋川芎嗪或三七十川芎联合用药治疗失血性休克晚期家兔，可明显提高ＳＯＤ活性，降低ＭＤＡ、ＢＬ及Ｍｇ２＋浓度。与单一药物组相比，证实前者可减半用药剂量，达到减轻其降压、法慢心率等负性变力变频作用，但却可取得超过各单一药物应用全量时的清除氧自由基效果。丹参正交实验结果显示：再灌注前若经动脉途径先轮入丹参，再同时使用携平衡盐液治疗，则可使组织细胞的损伤减轻到最低程度。
We established a model of advanced hemorrhagic shock in rabbits according to the Wigger method. The results showed that erythrocyte superoxide dismutase (SOD) activity in rabbits with hemorrhagic shock was significantly decreased, plasma MDA, BL and Mg2 + concentrations increased significantly Late shock exists by the oxygen free radicals caused by cell membrane lipid peroxidation damage. We will Salvia + ligustrazine or seventy Chuanxiong combined treatment of advanced hemorrhagic shock rabbits, can significantly improve the activity of SOD, reduce the concentration of MDA, BL and Mg2 +. Compared with the single drug group, it was confirmed that the former can reduce the dose by half and achieve the effect of alleviating the negative variable force such as blood pressure lowering and French slow heart rate, but can achieve the effect of scavenging oxygen free radicals more than the total amount of each single drug. Danshen orthogonal test results show that: before reperfusion if the first pass through the artery route Salvia, and then use the balanced salt solution treatment, you can minimize the damage of tissue cells.