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【目的】探讨血肌酐(SCr)、尿素氮(BUN)在小鼠肾脏缺血再灌注损伤(IRI)中的表达及其意义。【方法】以雄性 C57BL/6J 小鼠为研究对象,随机分为小鼠肾脏 IRI 模型(IR 组)、假手术模型(S 组)和对照组(C 组),检测各组小鼠不同时间点 SCr、BUN 水平,并分析其肾组织及肺组织病理损害程度。【结果】C 组、S组不同时间点 SCr 及 BUN 水平比较无显著差异(P >0.05),IR 组在再灌注后0 h 至7 d 呈逐渐升高而后降低的趋势,24 h 达到峰值。C 组、S 组不同时间点肾小管间质损伤及肺病理损伤评分比较均无显著差异(P >0.05),在 IR 组同样表现为先升高而后降低的趋势,肾小管间质损伤病理评分于再灌注24 h 达到最高峰,肺脏病理损害及评分在48~72 h 达到最高峰。【结论】小鼠肾脏 IRI 模型是稳定的急性肾损伤(AKI)模型,建模成功率高；缺血性 AKI 可诱导肺部的炎症反应,诱发急性肺损伤(ALI)。“,”[Objective]To investigate the occurrence and progress of serum creatinine and urea nitrogen in ischemia-reperfusion of mice kidney injury.[Methods]Male mice (C57BL/6J)used as subjects were randomly distributed in three groups:the ischemia-reperfusion group (IR),the sham surgery group (S)and the control group (C),and the SCr and UN levels of the 3 groups at different time points and the their kidney/lung tissue pathological damage were detected and analyzed.[Results]Levels of SCr and UN showed no significant differ-ence in the Group C and the Group S (P >0.05).From 0h to 7d following reperfusion,the SCr and UN levels gradually increased and then decreased,and reached the peak value 24h after reperfusion .The interstitial dam-age score of renal tubules and pathological damage score of lung injury at different time points presented com-paratively no significant difference between group C and group S (P >0.05).The IR Group presents the same tendency ,increasing first ,than decreasing ,the pathological grading of renal tubular interstitial injury reached the peak value 24h after reperfusion;Pathological damage score of lung injury reached the peak value in 48~72 h.[Conclusion]The mice model of ischemia-reperfusion renal injury is one steady animal model for research of Acute kidney injury(AKI),and ischemia AKI may induce pulmonary inflammatory reaction,and bring out a-cute kidney injury(AKI)as well.