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目的:评价黄芪注射液联合炎琥宁注射液治疗小儿手足口病合并心肌炎的临床疗效,探讨黄芪注射液对炎琥宁注射液治疗小儿手足口病合并心肌炎的疗效。方法:92例患者随机分成两组:对照组(N=46)和观察组(N=46),对照组除了常规的退烧,补液及补充维生素C之外给予炎琥宁注射液10 mg/kg加入100 ml 5%GS中进行静脉滴注;观察组在此基础上加黄芪注射液20 g/kg加入5%GS中进行静脉滴注,7日一疗程,1次/日。治疗结束后,分别对两组患者的心肌酶谱及超敏C反应蛋白等进行检测,统计分析检测结果。结果:观察组患儿总有效率97.8%,对照组患儿总有效率(95.7%);与对照组治疗后相比,观察组治疗后AST,LDH显著低于对照组治疗后;与对照组治疗后相比,观察组hs-CRP及TNF-α水平显著低于对照组治疗后。结论:黄芪注射液联合炎琥宁注射液对小儿手足口病合并心肌炎患儿的疗效优于单独使用炎琥宁注射液。
Objective: To evaluate the clinical efficacy of Radix Astragali combined with Yanhuning Injection in the treatment of hand, foot and mouth disease in children with myocarditis, and to investigate the therapeutic effect of Radix Astragali Injection on Infantile Foot-and-Mouth Disease with myocarditis. Methods: Ninety-two patients were randomly divided into two groups: control group (N = 46) and observation group (N = 46). The control group was given Yanhuoning injection 10 mg / kg Add 100 ml of 5% GS for intravenous drip; the observation group on this basis plus Astragalus injection 20 g / kg added 5% GS for intravenous infusion, 7 days a course of treatment, 1 time / day. After the treatment, respectively, the two groups of patients with myocardial enzymes and high-sensitivity C-reactive protein detection, statistical analysis of test results. Results: The total effective rate was 97.8% in the observation group and 95.7% in the control group. Compared with the control group, AST and LDH in the observation group were significantly lower than those in the control group after treatment Compared with the control group, the levels of hs-CRP and TNF-α in the observation group were significantly lower than those in the control group after treatment. Conclusion: Astragalus injection combined with Yanhuoning injection in infants with hand, foot and mouth disease in children with myocarditis better than the single use of Yanhuoning injection.