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目的探讨N-乙酰基-丝氨酰-天门冬酰-赖氨酰-脯氨酸(AcSDKP)在给药剂量(800μg·kg-1.d-1)下对染尘大鼠造血系统的影响。方法经气管给大鼠注入游离二氧化硅粉尘,并给予AcSDKP。通过血常规、骨髓涂片及血药浓度检测观察AcSDKP对造血系统的影响。结果红细胞、血小板计数和原始粒细胞、有核红细胞和原始淋巴细胞总数在各组间差异无显著性(P>0.05);而白细胞计数在染尘组和AcSDKP治疗组均较对照组增高约1.3倍。结论AcSDKP在一定给药剂量下对大鼠造血系统没有明显抑制作用。
Objective To investigate the effect of AcSDKP on the hematopoietic system in the exposed rats at the dose of 800μg · kg-1.d-1 . Methods Rats were injected with free silica dust via trachea and AcSDKP was given. The effect of AcSDKP on hematopoietic system was observed by blood routine test, bone marrow smear test and plasma concentration test. Results The number of erythrocytes, platelet count and the total number of primitive granulocytes, erythroblasts and primitive lymphocytes in each group were not significantly different (P> 0.05), while the white blood cell count was increased by about 1.3 in both the dust-treated group and the AcSDKP-treated group Times Conclusion AcSDKP did not significantly inhibit the hematopoietic system in a certain dose.